Inhibitory effect of epigallocatechin-3-O-gallate on &#945;-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells.

Xu, Leilei; Li, Weiwei; Chen, Zhongqin; Guo, Qingwen; Wang, Chunli; Santhanam, Ramesh Kumar; Chen, Haixia

Inhibitory effect of epigallocatechin-3-O-gallate on α-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells.

Xu, Leilei; Li, Weiwei; Chen, Zhongqin; Guo, Qingwen; Wang, Chunli; Santhanam, Ramesh Kumar; Chen, Haixia.

Afiliación

Xu L; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Li W; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Chen Z; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Guo Q; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Wang C; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Santhanam RK; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Chen H; Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: chenhx@tju.edu.cn.

Int J Biol Macromol ; 125: 605-611, 2019 Mar 15.

Article en En | MEDLINE | ID: mdl-30529552

Asunto(s)

Catequina/análogos & derivados; Inhibidores de Glicósido Hidrolasas/farmacología; Hipoglucemiantes/farmacología; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal/efectos de los fármacos; alfa-Glucosidasas/metabolismo; Acarbosa/metabolismo; Animales; Transporte Biológico/efectos de los fármacos; Catequina/farmacología; Línea Celular; Membrana Celular/efectos de los fármacos; Membrana Celular/metabolismo; Glucosa/metabolismo; Transportador de Glucosa de Tipo 4/metabolismo; Simulación del Acoplamiento Molecular; Fibras Musculares Esqueléticas/efectos de los fármacos; Fibras Musculares Esqueléticas/metabolismo; Polifenoles/farmacología; Ratas; Té/química

Palabras clave

EGCG; Inhibitory mechanisms; L6 myotubes; Molecular docking; α-Glucosidase

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Catequina / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Alfa-Glucosidasas / Inhibidores de Glicósido Hidrolasas / Hipoglucemiantes Idioma: En Revista: Int J Biol Macromol Año: 2019 Tipo del documento: Article

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