Bioactive secondary metabolites from an endophytic fungus Phoma sp. PF2 derived from Artemisia princeps Pamp.
J Antibiot (Tokyo)
; 72(3): 174-177, 2019 03.
Article
en En
| MEDLINE
| ID: mdl-30542160
ABSTRACT
Two new isochromanone derivatives, (3S,4S)-3,8-dihydroxy-6-methoxy-3,4,5-trimethylisochroman-1-one (1) and methyl (S)-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate (2), together with six known compounds (3â8) were isolated from the cultures of an endophytic fungus Phoma sp. PF2 obtained from Artemisia princeps. The chemical structures of the isolated compounds were elucidated by interpretation of spectroscopic data (1D, 2D NMR, HRESIMS, and CD) and calculation of ECD. All the isolated compounds (1â8) showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 machrophage cells.
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1
Bases de datos:
MEDLINE
Asunto principal:
Ascomicetos
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Productos Biológicos
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Artemisia
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Endófitos
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Inmunosupresores
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2019
Tipo del documento:
Article