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Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii.
Mofidi Tabatabaei, Sahar; Nejad Ebrahimi, Samad; Salehi, Peyman; Sonboli, Ali; Tabefam, Marzieh; Kaiser, Marcel; Hamburger, Matthias; Moridi Farimani, Mahdi.
Afiliación
  • Mofidi Tabatabaei S; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
  • Nejad Ebrahimi S; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
  • Salehi P; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
  • Sonboli A; Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
  • Tabefam M; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.
  • Kaiser M; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Hamburger M; University of Basel, Basel, Switzerland.
  • Moridi Farimani M; Pharmaceutical Biology, Pharmacenter, University of Basel, Basel, Switzerland.
Planta Med ; 85(5): 424-430, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30620946
ABSTRACT
A phytochemical investigation of extracts from flowers and aerial parts of Tanacetum sonbolii afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The in vitro antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4 and 5 showed IC50 values of 5.1 and 10.2 µM and selectivity indices of 3.9 and 4.0, respectively.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trypanosoma brucei rhodesiense / Tanacetum / Sesquiterpenos de Germacrano / Lactonas / Antiprotozoarios Idioma: En Revista: Planta Med Año: 2019 Tipo del documento: Article País de afiliación: Irán
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Trypanosoma brucei rhodesiense / Tanacetum / Sesquiterpenos de Germacrano / Lactonas / Antiprotozoarios Idioma: En Revista: Planta Med Año: 2019 Tipo del documento: Article País de afiliación: Irán