Maternal choline supplementation ameliorates Alzheimer's disease pathology by reducing brain homocysteine levels across multiple generations.

Velazquez, Ramon; Ferreira, Eric; Winslow, Wendy; Dave, Nikhil; Piras, Ignazio S; Naymik, Marcus; Huentelman, Matthew J; Tran, An; Caccamo, Antonella; Oddo, Salvatore

Velazquez, Ramon; Ferreira, Eric; Winslow, Wendy; Dave, Nikhil; Piras, Ignazio S; Naymik, Marcus; Huentelman, Matthew J; Tran, An; Caccamo, Antonella; Oddo, Salvatore.

Afiliación

Velazquez R; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Ferreira E; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Winslow W; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Dave N; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Piras IS; Translational Genomics Research Institute, Phoenix, AZ, USA.
Naymik M; Translational Genomics Research Institute, Phoenix, AZ, USA.
Huentelman MJ; Translational Genomics Research Institute, Phoenix, AZ, USA.
Tran A; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Caccamo A; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Oddo S; Arizona State University-Banner Neurodegenerative Disease Research Center at the Biodesign Institute, Arizona State University, Tempe, AZ, USA. oddo@asu.edu.

Mol Psychiatry ; 25(10): 2620-2629, 2020 10.

Article en En | MEDLINE | ID: mdl-30622336

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Enfermedad de Alzheimer/patología; Encéfalo/metabolismo; Colina/farmacología; Suplementos Dietéticos; Homocisteína/metabolismo; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/metabolismo; Animales; Colina/administración & dosificación; Modelos Animales de Enfermedad; Femenino; Masculino; Ratones; Ratones Transgénicos

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Encéfalo / Colina / Suplementos Dietéticos / Enfermedad de Alzheimer / Homocisteína Idioma: En Revista: Mol Psychiatry Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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