Pheophorbide A from Gelidium amansii improves postprandial hyperglycemia in diabetic mice through α-glucosidase inhibition.
Phytother Res
; 33(3): 702-707, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30648298
ABSTRACT
This study was designed to determine the inhibitory effects of pheophorbide A on carbohydrate digesting enzymes and its ability to improve postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. Pheophorbide A caused noticeable inhibitory effects on α-glucosidase and α-amylase, with half-maximal inhibitory concentrations (IC50 ) of 80.65 ± 5.90 and 76.48 ± 6.31 µM, respectively. The pheophorbide-mediated inhibition of α-glucosidase and α-amylase was significantly more effective than that of the positive control, acarbose. The increase in postprandial blood glucose levels was more significantly suppressed in the pheophorbide A group than in the control group of STZ-induced diabetic mice. In addition, the area under the curve was decreased by pheophorbide A intake in STZ-induced diabetic mice. Our results suggested that pheophorbide A may help to improve postprandial hyperglycemia by inhibiting the activity of carbohydrate digesting enzymes.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Clorofila
/
Diabetes Mellitus Experimental
/
Rhodophyta
/
Inhibidores de Glicósido Hidrolasas
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Hiperglucemia
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Phytother Res
Año:
2019
Tipo del documento:
Article