Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity.
Molecules
; 24(2)2019 Jan 17.
Article
en En
| MEDLINE
| ID: mdl-30658485
ABSTRACT
Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis Aâ»E (1â»5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1â»5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 µM compared to Cisplatin.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Triterpenos
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Cucurbitaceae
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Tubérculos de la Planta
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Glicósidos
Idioma:
En
Revista:
Molecules
Año:
2019
Tipo del documento:
Article
País de afiliación:
China