A new methylene bisflavan-3-ol from the branches and leaves of Potentilla fruticosa.
Nat Prod Res
; 34(9): 1238-1245, 2020 May.
Article
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| MEDLINE
| ID: mdl-30663382
ABSTRACT
Dasiphora fruticosa L. (Rosaceae), also known as Potentilla fruticosa L. (syn.), is a hardy deciduous shrub widely distributed in the north temperate regions of the world. Three methylene bisflavan-3-ols (1-3), together with a procyanidin dimer, (-)-afzelechin-(4αâ8)-(-)-afzelechin (4) were isolated for the first time from the branches and leaves of the titled plant, in addition to 11 known compounds (5-15). Their structures were elucidated by means of extensive spectroscopic analysis and by comparison with data reported in the literatures. Methylene 6,8-bis(7-O-glucosyl) catechin (1) was determined to be a new dimeric flavan-3-ol glycoside through a methylene linkage between C-8 and C-8 of two units. At a concentration of 128 µg/mL, the known compounds 9 - 13 exhibited antibacterial activities on Escherichia coli, Staphylococcus aureus subsp. aureus, Salmonella enterica subsp. enterica, and Pseudomonas aeruginosa. Compound 12 also showed certain glucose uptake stimulating activity.
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Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Flavonoides
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Rosaceae
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Potentilla
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Antibacterianos
Idioma:
En
Revista:
Nat Prod Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
China