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Epidemiological Profile and Antimicrobial Resistance Pattern of Enteric Fever in a Tertiary Care Hospital of North India - a Seven Year Ambispective Study.
Makkar, Anuradha; Gupta, Shilpi; Khan, Inam Danish; Gupta, Rajiv Mohan; Rajmohan, K S; Chopra, Harleen; Gupta, Manisha; Bansal, Sachin; Poonia, Bindu; Malik, Muqtadir; Panda, Pragyan Swagatika.
Afiliación
  • Makkar A; Army College of Medical Sciences and Base Hospital, New Delhi, India.
  • Gupta S; Department of Microbiology, MH Bhopal, India.
  • Khan ID; Army College of Medical Sciences and Base Hospital, New Delhi, India. titan_afmc@yahoo.com.
  • Gupta RM; Army Hospital Research and Referral, New Delhi 110010, India.
  • Rajmohan KS; Army College of Medical Sciences and Base Hospital, New Delhi, India.
  • Chopra H; Army College of Medical Sciences and Base Hospital, New Delhi, India.
  • Gupta M; Sanjay Gandhi Post-Graduate Institute, Lucknow, India.
  • Bansal S; Dr Lal Path Labs, Tilak nagar, New Delhi, India.
  • Poonia B; Army College of Medical Sciences and Base Hospital, New Delhi, India.
  • Malik M; Army Hospital Research and Referral, New Delhi 110010, India.
  • Panda PS; Army College of Medical Sciences and Base Hospital, New Delhi, India.
Acta Medica (Hradec Kralove) ; 61(4): 125-130, 2018.
Article en En | MEDLINE | ID: mdl-30664444
ABSTRACT

INTRODUCTION:

Enteric-fever is a major public-health problem in developing countries emerging as multidrug-resistant, Nalidixic-acid resistant and extremely drug-resistant Salmonella (Pakistan, 2016), has intensified the use of WHO watch/reserve group antimicrobials such as azithromycin and meropenem.

METHODS:

This ambispective-study was conducted on 782 non-repeat blood-culture isolates of S. Typhi, S. Paratyphi A and S. Paratyphi B obtained from 29,184 blood cultures received at a 1000-bedded tertiary-care hospital of North-India from 2011-2017. Identification and antibiograms were obtained by Vitek-2 compact and Kirby-Bauer's disc diffusion with resistance to ampicillin, chloramphenicol and cotrimoxazole being labeled as multidrug-resistant. Decreased ciprofloxacin-susceptibility and ciprofloxacin-resistance were defined as MIC 0.125-0.5 and >1 µg/ml.

RESULTS:

S. Typhi and S. Paratyphi A in a ratio of 3.91 were seen between July-September predominantly distributed between 6-45 year age group. Resistance to co-trimoxazole, chloramphenicol, ceftriaxone and azithromycin was 6.1%, 13.8%, 16.1 and 5.78% respectively. Multidrug-resistant S. typhi and S. paratyphi A were 2.73% and 1.91% respectively.

CONCLUSION:

Enteric-fever is a major public-health problem in India. Emergence of multidrug-resistant, Nalidixic-acid resistant and extremely-drug resistant Salmonella mandates ongoing surveillance for targeted empirical therapy and containment of spread. Repeated epidemics call for water, sanitation, hygiene and vaccination strategies to sustain herd-immunity.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Fiebre Tifoidea / Antibacterianos País/Región como asunto: Asia Idioma: En Revista: Acta Medica (Hradec Kralove) Año: 2018 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Fiebre Tifoidea / Antibacterianos País/Región como asunto: Asia Idioma: En Revista: Acta Medica (Hradec Kralove) Año: 2018 Tipo del documento: Article País de afiliación: India