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4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
Meyers, Marvin J; Liu, Jianguang; Xu, Jing; Leng, Fang; Guan, Jiantong; Liu, Zhijun; McNitt, Sarah A; Qin, Limei; Dai, Linglin; Ma, Hongwei; Adah, Dickson; Zhao, Siting; Li, Xiaofen; Polino, Alex J; Nasamu, Armiyaw S; Goldberg, Daniel E; Liu, Xiaorong; Lu, Yongzhi; Tu, Zhengchao; Chen, Xiaoping; Tortorella, Micky D.
Afiliación
  • Meyers MJ; Department of Chemistry , Saint Louis University , Saint Louis , Missouri 63103 , United States.
  • Liu J; Center for World Health and Medicine , Saint Louis University School of Medicine , Saint Louis , Missouri 63104 , United States.
  • Xu J; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Leng F; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Guan J; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Liu Z; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • McNitt SA; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Qin L; Department of Chemistry , Saint Louis University , Saint Louis , Missouri 63103 , United States.
  • Dai L; Center for World Health and Medicine , Saint Louis University School of Medicine , Saint Louis , Missouri 63104 , United States.
  • Ma H; Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Adah D; Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Zhao S; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Li X; Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Polino AJ; University of Chinese Academy of Sciences , Beijing 100049 , China.
  • Nasamu AS; Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Goldberg DE; Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center of Infection and Immunity , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Liu X; Departments of Medicine and Molecular Microbiology , Washington University in St. Louis , Saint Louis , Missouri 63110 , United States.
  • Lu Y; Departments of Medicine and Molecular Microbiology , Washington University in St. Louis , Saint Louis , Missouri 63110 , United States.
  • Tu Z; Departments of Medicine and Molecular Microbiology , Washington University in St. Louis , Saint Louis , Missouri 63110 , United States.
  • Chen X; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
  • Tortorella MD; Drug Discovery Pipeline at the Guangzhou Institutes for Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530 , China.
J Med Chem ; 62(7): 3503-3512, 2019 04 11.
Article en En | MEDLINE | ID: mdl-30856324
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirrolidinas / Antimaláricos Idioma: En Revista: J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirrolidinas / Antimaláricos Idioma: En Revista: J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos