Trichothecenes from a Soil-Derived Trichoderma brevicompactum.
J Nat Prod
; 82(4): 687-693, 2019 04 26.
Article
en En
| MEDLINE
| ID: mdl-30860372
ABSTRACT
Six new (1-6), together with seven known (7-13), trichothecenes were isolated from the soil-derived Trichoderma brevicompactum PSU-RSPG27. Their structures were established using spectroscopic data. The structure of 1 was confirmed by X-ray data. Trichodermin (7) exhibited the most potent activity against Plasmodium falciparum (K1 strain) with an IC50 value of 0.1 µM, while other trichothecenes (1, 8, 9, and 12) were much less active, with IC50 values in the range of 7.1-9.6 µM. Compound 7 displayed activity against noncancerous Vero cells with an IC50 value of 0.4 µM. The remaining compounds showed moderate to weak activity, with IC50 values in the range of 6.9-15.3 µM. Compounds 7 and 12 were active against human oral carcinoma (KB) cells with IC50 values of 2.4 and 3.7 µM, respectively. Additionally, compounds 7 and 12 displayed antifungal activity against Candida albicans with the respective MIC values of 1 and 2 µg/mL and were active against Cryptococcus neoformans with equal MIC values of 4 µg/mL.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Microbiología del Suelo
/
Trichoderma
/
Tricotecenos
Idioma:
En
Revista:
J Nat Prod
Año:
2019
Tipo del documento:
Article
País de afiliación:
Tailandia