Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience.
Nat Hum Behav
; 3(1): 63-73, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30932053
ABSTRACT
Real-time functional magnetic resonance imaging (rt-fMRI) has revived the translational perspective of neurofeedback (NF)1. Particularly for stress management, targeting deeply located limbic areas involved in stress processing2 has paved new paths for brain-guided interventions. However, the high cost and immobility of fMRI constitute a challenging drawback for the scalability (accessibility and cost-effectiveness) of the approach, particularly for clinical purposes3. The current study aimed to overcome the limited applicability of rt-fMRI by using an electroencephalography (EEG) model endowed with improved spatial resolution, derived from simultaneous EEG-fMRI, to target amygdala activity (termed amygdala electrical fingerprint (Amyg-EFP))4-6. Healthy individuals (n = 180) undergoing a stressful military training programme were randomly assigned to six Amyg-EFP-NF sessions or one of two controls (control-EEG-NF or NoNF), taking place at the military training base. The results demonstrated specificity of NF learning to the targeted Amyg-EFP signal, which led to reduced alexithymia and faster emotional Stroop, indicating better stress coping following Amyg-EFP-NF relative to controls. Neural target engagement was demonstrated in a follow-up fMRI-NF, showing greater amygdala blood-oxygen-level-dependent downregulation and amygdala-ventromedial prefrontal cortex functional connectivity following Amyg-EFP-NF relative to NoNF. Together, these results demonstrate limbic specificity and efficacy of Amyg-EFP-NF during a stressful period, pointing to a scalable non-pharmacological yet neuroscience-based training to prevent stress-induced psychopathology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
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Síntomas Afectivos
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Resiliencia Psicológica
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Ondas Encefálicas
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Neurorretroalimentación
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Amígdala del Cerebelo
Tipo de estudio:
Clinical_trials
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Prognostic_studies
Idioma:
En
Revista:
Nat Hum Behav
Año:
2019
Tipo del documento:
Article
País de afiliación:
Israel