A new phthalazinone derivative and a new isoflavonoid glycoside from lichen-associated Amycolatopsis sp.
Fitoterapia
; 135: 85-89, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-31028818
ABSTRACT
A new phthalazinone derivative, named amycophthalazinone A (1), and a new isoflavonoid glycoside, 7-O-methyl-5-O-α-L-rhamnopyranosylgenestein (2), along with an isoflavonoid glycoside, 7-O-α-D-arabinofuranosyl daidzein (3) firstly found from natural sources, and eight known compounds (4-11), were isolated from the culture broth of the lichen-associated Amycolatopsis sp. YIM 130642. The structures of new compounds were elucidated on the basis of spectroscopic analysis. Compound 1 was the first example of naturally occurring phthalazinone derivative. The antimicrobial activities of all compounds towards five pathogenic strains were evaluated by a broth microdilution assay. Compound 1 exhibited the most potent inhibitory activity against Staphylococcus aureus, Salmonella typhi, and Candida albicans with MIC values of 32, 32, and 64⯵g/mL, respectively.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ftalazinas
/
Actinobacteria
/
Glicósidos
/
Isoflavonas
/
Líquenes
/
Antiinfecciosos
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Fitoterapia
Año:
2019
Tipo del documento:
Article
País de afiliación:
China