Hypothalamic impairment underlying heat intolerance in pregnant mice.
Mol Cell Endocrinol
; 492: 110439, 2019 07 15.
Article
en En
| MEDLINE
| ID: mdl-31071379
ABSTRACT
Pregnant women are vulnerable to heat stroke reactions caused by high environmental temperatures. Heat intolerance is associated with hypothalamic impairment. Here, we aim to ascertain whether pregnancy causes heat intolerance by inducing hypothalamic impairment in mice. In the heated groups, mice were exposed to whole body heating (WBH; 41.2⯰C for 1â¯h) in an environment-controlled chamber. Then, they were returned to normal room temperature (26⯰C) immediately after WBH. In the hyperbaric oxygen therapy (HBO2T) groups, mice were exposed to 100% O2 at 2.0â¯atm absolute (ATA) for 4â¯h immediately post-WBH. Mice that survived after 4â¯h of WBH were considered survivors. Here, we show that when pregnant mice underwent non-HBO2T (21% O2 at 1.0 ATA for 4â¯h) after WBH, the survival rate was 4/20, and the core temperature at 4â¯h post-WBH was 31.2⯱â¯0.2⯰C. Both the survival rate and core temperature of HBO2T pregnant mice (10/10 and 35.2⯱â¯0.3⯰C, respectively) were significantly greater than those in non-HBO2T pregnant mice. Compared to non-HBO2T heated mice, the HBO2T heated mice exhibited lower neurological severity scores, reduced hypothalamic neuronal damage, fewer apoptotic cells, reduced multiorgan damage scores, and lower hypothalamic levels of proinflammatory cytokines and nitrogen and oxygen radical species. Compared to non-HBO2T heated mice, the HBO2T-treated heated mice had significantly higher hypothalamic-pituitary-adrenal axis activity (evidenced by higher serum levels of both adrenocorticotrophic hormone and corticosterone). In conclusion, pregnancy induces heat intolerance by inducing hypothalamic impairment in mice. Additionally, HBO2T protects against heat intolerance in pregnant mice by preserving hypothalamic integrity.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Asunto principal:
Complicaciones del Embarazo
/
Golpe de Calor
/
Calor
/
Oxigenoterapia Hiperbárica
/
Hipotálamo
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán