Prophylactic management for taxane-induced nail toxicity: A systematic review and meta-analysis.
Eur J Cancer Care (Engl)
; 28(5): e13118, 2019 Sep.
Article
en En
| MEDLINE
| ID: mdl-31184794
ABSTRACT
OBJECTIVE:
This meta-analysis was performed to assess the efficacy of cryotherapy and nail solution (NS) use in preventing nail toxicity (NT) induced by taxane-based chemotherapy.METHODS:
PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov registry databases were searched for relevant studies published up to December 2018. The primary outcome was taxane-induced NT. Secondary outcomes were skin toxicity (ST), time to toxicity and patient comfort.RESULTS:
We reviewed three randomised control trials and six prospective studies with 708 patients. For meta-analysis, taxane-induced NT grading was compared. NT and ST were significantly lower in the cryotherapy patients than in the controls (grade 1 NT risk ratio [RR] = 0.51, 95% confidence interval [CI] = 0.30-0.89; grade 2-3 NT RR = 0.36, 95% CI = 0.11-1.12; total NT RR = 0.49; 95% CI = 0.30-0.79; ST RR = 0.46, 95% CI = 0.33-0.64). The NS-treated patients exhibited significantly lower NT than the controls.CONCLUSIONS:
Nail solution-treated or cryotherapy patients exhibited lower NT incidence and severity associated with taxane-based chemotherapy than the controls. For patients who can afford and comply with NS use or cryotherapy, these measures represent effective prophylactic management for taxane-induced NT and improve their quality of life and functional statuses. Further studies are needed to establish the routine usage protocols, long-term efficacy and safety for these interventions.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Asunto principal:
Ceras
/
Aceites de Plantas
/
Aceites Volátiles
/
Crioterapia
/
Taxoides
/
Enfermedades de la Uña
/
Neoplasias
Tipo de estudio:
Clinical_trials
/
Guideline
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Revista:
Eur J Cancer Care (Engl)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán