Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate.
Regul Toxicol Pharmacol
; 107: 104404, 2019 Oct.
Article
en En
| MEDLINE
| ID: mdl-31199997
ABSTRACT
Hyperlipidemia is a serious health threat that has been linked to oxidative stress and systemic inflammation, causing among many other disorders essentially liver disease. The current study was conducted to evaluate the antihyperlipidemic, antioxidant and anti-inflammatory potential of methanol leaf extract from Erica multiflora (M-EML). Triton WR-1339-induced hyperlipidemic rats were divided into six groups control group (CG), hyperlipidemic group (300â¯mg/kg body weight "BW") (HG), hyperlipidemic group treated with M-EML (150 and 250â¯mg/kg) (HG + M-EML), normal rats treated with M-EML (250â¯mg/kg) and fenofibrate-treated group (HG + FF) (65â¯mg/kg). After 24â¯h of administration, triton WR-1339 induced a significant increase in lipid profile, atherogenic index (AI) and Coronary Risk Index (CRI) in HG group compared to control group. Furthermore, triton WR-1339 administration induced alteration in the status of pro-inflammatory markers (aspartate transaminase, alanine transaminase, IFN-γ and Nitric oxide production). HG group showed also, a high level of lipid peroxidation, an altered antioxidant enzyme profiles and an increase in DNA damages, in liver. However, orally administration of M-EML mitigates significantly these disorders, proving hence a protective potential against triton WR-1339-induced hyperlipidemia. These findings suggest that M-EML extract could be used as functional foods and natural adjuvant treatment of hyperlipidemia.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Extractos Vegetales
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Ericaceae
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Hiperlipidemias
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Antiinflamatorios
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Hipolipemiantes
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Antioxidantes
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Año:
2019
Tipo del documento:
Article