Evaluation of Vitamin D Levels and Response to Therapy of Childhood Migraine.
Medicina (Kaunas)
; 55(7)2019 Jun 28.
Article
en En
| MEDLINE
| ID: mdl-31261815
ABSTRACT
BACKGROUND AND OBJECTIVES:
Vitamin D deficiency and insufficiency are related with many neurological diseases such as migraine. The aim of this study was to investigate whether pediatric migraine is associated with vitamin D deficiency and the effect of vitamin D therapy on the frequency, duration, severity of migraine attacks, and Pediatric Migraine Disability Assessment (PedMIDAS). MATERIALS ANDMETHODS:
We retrospectively examined the patients' levels of calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-OH vitamin D of 92 pediatric migraine patients. The patients were divided into two groups Group 1, which had low vitamin D levels and received vitamin D therapy, and group 2, which had normal vitamin D levels and did not receive vitamin D therapy. Migraine severity measured by the visual analog scale (VAS), migraine frequency, and duration as well as scores on the PedMIDAS questionnaire were compared with regard to the 25-OH vitamin D levels. In addition, pre- and posttreatment pedMIDAS scores, VAS, migraine frequency, and duration were compared with baseline values.RESULTS:
A total of 34.7% patients had vitamin D insufficiency (vitamin D levels between 10 and 20 ng/mL), whereas 10.8% had vitamin D deficiency (vitamin D levels < 10 ng/mL). Migraine frequency, migraine duration, and PedMIDAS scores were significantly higher in the group 1 than group 2 (p = 0.004, p = 0.008, and p = 0.001). After vitamin D therapy at sixth months of supplementation, migraine duration was reported statistically significant shorter (p < 0.001) and the migraine frequency, VAS scores, and pedMIDAS scores were statistically significant lower compared with baseline values in group 1 (p < 0.001).CONCLUSION:
We found a marked correlation between pediatric migraine and vitamin D levels. Vitamin D therapy was beneficial in migraine pediatric patients.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina D
/
Trastornos Migrañosos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Medicina (Kaunas)
Año:
2019
Tipo del documento:
Article
País de afiliación:
Turquía