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Cytotoxic phenolic compounds isolated from the fruits of Macaranga denticulata.
Le, Tran Nguyen Vu; Truong, Bich Ngan; Le, Thi Phuong; Litaudon, Marc; Tran, Dang Thach; Chau, Van Minh; Mai, Huong Doan Thi; Pham, Van Cuong.
Afiliación
  • Le TNV; Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam.
  • Truong BN; Faculty of Chemistry, Graduate University of Science and Technology, VAST, Caugiay, Hanoi, Vietnam.
  • Le TP; Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam.
  • Litaudon M; Faculty of Chemistry, Graduate University of Science and Technology, VAST, Caugiay, Hanoi, Vietnam.
  • Tran DT; Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam.
  • Chau VM; Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Mai HDT; Institute of Applied Science and Technology, University Industry Vinh, Vinh, Vietnam.
  • Pham VC; Advanced Center for Bioorganic Chemistry, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Hanoi, Vietnam.
Nat Prod Res ; 35(11): 1861-1868, 2021 Jun.
Article en En | MEDLINE | ID: mdl-31293177
A new modified geranylated flavonoid, 3'-dehydroxy-solophenol C (1), along with 17 known compounds (2-18) were isolated from the fruits of Macaranga denticulata. Their structures were established by spectral analysis, such as mass spectrometry, 1D-NMR and 2D-NMR. The new geranylated flavonoid 1 showed a moderate cytotoxic activity against the A549 cell line with IC50 value of 16.0 µM. Compound 9 showed the highest cytotoxic activities against KB, HepG2, Lu-1 and MCF7 cell lines with IC50 values of 0.6, 0.8, 1.3 and 1.2 µM, respectively.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenoles / Euphorbiaceae / Frutas Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: Vietnam
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenoles / Euphorbiaceae / Frutas Idioma: En Revista: Nat Prod Res Año: 2021 Tipo del documento: Article País de afiliación: Vietnam