Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice.

Fan, Yong-Gang; Guo, Tian; Han, Xiao-Ran; Liu, Jun-Lin; Cai, Yu-Ting; Xue, Han; Huang, Xue-Shi; Li, Yan-Chun; Wang, Zhan-You; Guo, Chuang

Fan, Yong-Gang; Guo, Tian; Han, Xiao-Ran; Liu, Jun-Lin; Cai, Yu-Ting; Xue, Han; Huang, Xue-Shi; Li, Yan-Chun; Wang, Zhan-You; Guo, Chuang.

Afiliación

Fan YG; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Guo T; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Han XR; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Liu JL; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Cai YT; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Xue H; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Huang XS; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China.
Li YC; Department of Medicine, the University of Chicago, Chicago, IL 60637, USA.
Wang ZY; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China; Institute of Health Sciences, Key Laboratory of Medical Cell Biology of Ministry of Education, China Medical University, Shenyang 110122, China. Electronic address: wangzy@m
Guo C; College of Life and Health Sciences, Northeastern University, NO.195, Chuangxin Road, Hunnan District, Shenyang 110169, China. Electronic address: guoc@mail.neu.edu.cn.

EBioMedicine ; 45: 393-407, 2019 Jul.

Article en En | MEDLINE | ID: mdl-31303501

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Secretasas de la Proteína Precursora del Amiloide/genética; Ácido Aspártico Endopeptidasas/genética; Ergocalciferoles/farmacología; Neuronas/efectos de los fármacos; 8-Hidroxi-2'-Desoxicoguanosina/metabolismo; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/genética; Animales; Encéfalo/metabolismo; Encéfalo/patología; Calpaína/genética; Modelos Animales de Enfermedad; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/genética; Lisosomas/efectos de los fármacos; Lisosomas/genética; Ratones; Ratones Transgénicos; Mitocondrias/metabolismo; Neuronas/patología; Oligopéptidos/genética; Presenilina-1/genética; Proteolisis/efectos de los fármacos

Palabras clave

8-hydroxyguanosine; Alzheimer's disease; Lysosomal degradation; Neuronal loss; Paricalcitol; ß-Site APP cleavage enzyme 1

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ergocalciferoles / Ácido Aspártico Endopeptidasas / Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer / Neuronas Tipo de estudio: Prognostic_studies Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article País de afiliación: China

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