Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression.

Hu, Hui; Wang, Boshi; Jiang, Chunyu; Li, Ruiting; Zhao, Jungong

Hu, Hui; Wang, Boshi; Jiang, Chunyu; Li, Ruiting; Zhao, Jungong.

Afiliación

Hu H; Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai 200233, China.
Wang B; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Jiang C; Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai 200233, China.
Li R; Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai 200233, China.
Zhao J; Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai 200233, China zhaojungong@sjtu.edu.cn.

Clin Sci (Lond) ; 133(14): 1629-1644, 2019 07 31.

Article en En | MEDLINE | ID: mdl-31315970

Asunto(s)

Terapia Biológica; Traumatismos de las Arterias Carótidas/fisiopatología; Traumatismos de las Arterias Carótidas/terapia; Células Progenitoras Endoteliales/química; Exosomas/química; Células Endoteliales de la Vena Umbilical Humana/citología; MicroARNs/metabolismo; Trombospondina 1/genética; Animales; Traumatismos de las Arterias Carótidas/genética; Traumatismos de las Arterias Carótidas/metabolismo; Movimiento Celular; Proliferación Celular; Células Endoteliales de la Vena Umbilical Humana/metabolismo; Humanos; Masculino; MicroARNs/genética; Ratas; Ratas Sprague-Dawley; Trombospondina 1/metabolismo

Palabras clave

endothelial progenitor cell; exosomes; miR-21-5p; reendothelialization; thrombospondins

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Terapia Biológica / Trombospondina 1 / Traumatismos de las Arterias Carótidas / MicroARNs / Exosomas / Células Endoteliales de la Vena Umbilical Humana / Células Progenitoras Endoteliales Idioma: En Revista: Clin Sci (Lond) Año: 2019 Tipo del documento: Article País de afiliación: China

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