Evaluation of Oxasqualenoids from the Red Alga Laurencia viridis against Acanthamoeba.
Mar Drugs
; 17(7)2019 Jul 19.
Article
en En
| MEDLINE
| ID: mdl-31331002
ABSTRACT
Acanthamoeba genus is a widely distributed and opportunistic parasite with increasing importance worldwide as an emerging pathogen in the past decades. This protozoan has an active trophozoite stage, a cyst stage, and is dormant and very resistant. It can cause Acanthamoeba keratitis, an ocular sight-threatening disease, and granulomatous amoebic encephalitis, a chronic, very fatal brain pathology. In this study, the amoebicidal activity of sixteen Laurencia oxasqualenoid metabolites and semisynthetic derivatives were tested against Acanthamoeba castellanii Neff. The results obtained point out that iubol (3) and dehydrothyrsiferol (1) possess potent activities, with IC50 values of 5.30 and 12.83 µM, respectively. The hydroxylated congeners thyrsiferol (2) and 22-hydroxydehydrothyrsiferol (4), active in the same value range at IC50 13.97 and 17.00 µM, are not toxic against murine macrophages; thus, they are solid candidates for the development of new amoebicidal therapies.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Escualeno
/
Extractos Vegetales
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Laurencia
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Acanthamoeba castellanii
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Amebicidas
Idioma:
En
Revista:
Mar Drugs
Año:
2019
Tipo del documento:
Article
País de afiliación:
España