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A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections.
Chojnacki, Michaelle; Philbrick, Alesa; Scherzi, Tyler; Pecora, Nicole; Dunman, Paul M; Wozniak, Rachel A F.
Afiliación
  • Chojnacki M; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Philbrick A; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Scherzi T; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Pecora N; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Dunman PM; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
  • Wozniak RAF; Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA rachel_wozniak@urmc.rochester.edu.
Antimicrob Agents Chemother ; 63(10)2019 10.
Article en En | MEDLINE | ID: mdl-31332071
Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potent in vitro activity against Staphylococcus aureus and Pseudomonas aeruginosa, two important causes of keratitis. Here we further characterize this combination against P. aeruginosa in a murine keratitis model. PT plus rifampin performed comparably to or better than moxifloxacin, the gold standard, suggesting that the combination may be a promising therapy for bacterial keratitis.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Infecciones Bacterianas del Ojo / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Infecciones Bacterianas del Ojo / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos