Comparative study of rheological properties and preclinical data of porous polycaprolactone microsphere dermal fillers.
J Cosmet Dermatol
; 19(3): 596-604, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31347766
ABSTRACT
BACKGROUND:
In this study, a physical properties test and preclinical evaluation were performed on two polycaprolactone (PCL)-based dermal filler formulas.OBJECTIVE:
This study was performed to compare the rheological characteristics, preclinical efficacy, and safety of a new PCL filler, SF-01, with a licensed PCL filler.METHODS:
First, the viscoelasticity of the PCL filler was evaluated. Next, hairless mice were injected with fillers and evaluated for efficacy with a folliscope and PRIMOSLITE . Histological evaluation was conducted for 6 months to evaluate safety.RESULTS:
In this evaluation, SF-01 was superior to a licensed PCL filler in initial volume increase rate and in vivo durability, and the migration of the injected filler was not confirmed. The elasticity (G*, G') and viscosity (G'') are also expected to be lower than those of a licensed PCL filler, thereby resulting in less foreign body sensation in the living body.CONCLUSION:
SF-01 (porous PCL microsphere-based dermal filler) has been confirmed to be superior in durability and shape retention compared to the licensed PCL filler (nonporous PCL microsphere-based dermal filler), and the in vivo safety is equivalent.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Poliésteres
/
Piel
/
Técnicas Cosméticas
/
Rellenos Dérmicos
/
Microesferas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Cosmet Dermatol
Año:
2020
Tipo del documento:
Article