Changes in Intestinal Microbiota of Type 2 Diabetes in Mice in Response to Dietary Supplementation With Instant Tea or Matcha.
Can J Diabetes
; 44(1): 44-52, 2020 Feb.
Article
en En
| MEDLINE
| ID: mdl-31378691
ABSTRACT
OBJECTIVE:
Gut microbiota plays a key role in metabolism and health in diabetes patients with gastrointestinal microbiota dysbiosis. Thus, regulating the ecological balance of gut microbiota may provide a pathway toward improvement for these patients. Our previous study showed that functional ingredients in tea may inhibit cornstarch digestion in vitro.METHODS:
A cornstarch-tea diet was developed, and in this study we investigated the effects of such a diet on blood glucose and gut microbiota in diabetic mice.RESULTS:
Diabetes resulted in significant weight loss, hyperphagia and hyperglycemia. 16S rDNA sequencing revealed that in diabetes there is significantly increased Bacteroidaceae, Helicobacteraceae, Ruminococcaceae, Enterobacteriaceae, Rikenellaceae and Saccharibacteria_genera_incertae_sedis, and significantly decreased Lactobacillaceae, Prevotellaceae, Coriobacteriaceae, Verrucomicrobiaceae and Bifidobacteriaceae. The cornstarchâtea diet resulted in a trend toward reduced blood glucose, with particularly increased levels of Coriobacteriaceae, Lactobacillaceae, Prevotellaceae and Bifidobacteriaceae, and decreased Bacteroidaceae, Ruminococcaceae, Helicobacteraceae and Enterobacteriaceae.CONCLUSIONS:
Instant tea and matcha supplementation had beneficial effects on regulation of blood glucose and gut microbiota, reversing the changes in microbiota caused by alloxan injection. The cornstarchâtea regulation pathway is involved in bacterium group regulation rather than single-species regulation, which suggests that cornstarch combined with tea may be used as a functional food supplement for diabetes patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Té
/
Extractos Vegetales
/
Suplementos Dietéticos
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
/
Disbiosis
/
Microbioma Gastrointestinal
Idioma:
En
Revista:
Can J Diabetes
Año:
2020
Tipo del documento:
Article
País de afiliación:
China