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Hyaluronic acid-functionalized bilosomes for targeted delivery of tripterine to inflamed area with enhancive therapy on arthritis.
Yang, Hailing; Liu, Zhenjie; Song, Yonglong; Hu, Changjiang.
Afiliación
  • Yang H; a School of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu , China.
  • Liu Z; b School of Pharmacy, Guangxi University of Chinese Medicine , Nanning , China.
  • Song Y; b School of Pharmacy, Guangxi University of Chinese Medicine , Nanning , China.
  • Hu C; c Department of Pharmacy, Anhui Medical College , Hefei , China.
Drug Deliv ; 26(1): 820-830, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31389248
ABSTRACT
Arthritis treatment has been challenging because of low drug exposure to the articular cavity. This study was intended to develop hyaluronic acid (HA)-functionalized bilosomes for targeted delivery of tripterine (Tri), an antiphlogistic phytomedicine, to the inflamed joint via ligand-receptor interaction. Tri-loaded bilosomes (Tri-BLs) with cationic lipid (DOTAP) were prepared by a thin film hydration method followed by HA coating to form HA@Tri-BLs. HA@Tri-BLs were then characterized by particle size (PS), entrapment efficiency (EE), and structural morphology. The in vitro drug release, hemocompatibility test and cellular uptake were performed to examine the formulation performances of HA@Tri-BLs. The in vivo pharmacokinetics and antiarthritic efficacy were evaluated in arthritic models, respectively. The obtained HA@Tri-BLs possessed a PS of 118.5 nm around with an EE of 99.56%. HA@Tri-BLs exhibited excellent cellular uptake and targeted delivery efficiency for Tri, which resulted in elongation of circulatory residence time and enhancement of intra-arthritic bioavailability (799.9% relative to Tri solution). The in vivo antiarthritic efficacy of HA@Tri-BLs was also significantly superior to uncoated Tri-BLs that gave rise to obvious inflammation resolution. Our findings suggest that HA-functionalized bilosomes are a promising vehicle for articular delivery of antiphlogistic drugs to potentiate their efficacy.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Artritis / Triterpenos / Ácido Hialurónico / Inflamación / Liposomas Tipo de estudio: Prognostic_studies Idioma: En Revista: Drug Deliv Año: 2019 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Artritis / Triterpenos / Ácido Hialurónico / Inflamación / Liposomas Tipo de estudio: Prognostic_studies Idioma: En Revista: Drug Deliv Año: 2019 Tipo del documento: Article País de afiliación: China