4D cardiac electromechanical activation imaging.
Comput Biol Med
; 113: 103382, 2019 10.
Article
en En
| MEDLINE
| ID: mdl-31476587
ABSTRACT
Cardiac abnormalities, a major cause of morbidity and mortality, affect millions of people worldwide. Despite the urgent clinical need for early diagnosis, there is currently no noninvasive technique that can infer to the electrical function of the whole heart in 3D and thereby localize abnormalities at the point of care. Here we present a new method for noninvasive 4D mapping of the cardiac electromechanical activity in a single heartbeat for heart disease characterization such as arrhythmia and infarction. Our novel technique captures the 3D activation wave of the heart in vivo using high volume-rate (500 volumes per second) ultrasound with a 32â¯×â¯32 matrix array. Electromechanical activation maps are first presented in a normal and infarcted cardiac model in silico and in canine heart during pacing and re-entrant ventricular tachycardia in vivo. Noninvasive 4D electromechanical activation mapping in a healthy volunteer and a heart failure patient are also determined. The technique described herein allows for direct, simultaneous and noninvasive visualization of electromechanical activation in 3D, which provides complementary information on myocardial viability and/or abnormality to clinical imaging.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
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Procesamiento de Imagen Asistido por Computador
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Ecocardiografía
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Técnicas Electrofisiológicas Cardíacas
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Sistema de Conducción Cardíaco
Tipo de estudio:
Screening_studies
Idioma:
En
Revista:
Comput Biol Med
Año:
2019
Tipo del documento:
Article