Acquisition of FKS2 mutation after echinocandin treatment of infective endocarditis by Candida glabrata.
Infez Med
; 27(3): 328-331, 2019 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-31545778
ABSTRACT
Bloodstream infections caused by non-albicans Candida species are increasing and echinocandins have been extensively used especially in patients with hemodynamic instability, previous antifungal treatment and hospital risk factors for intrinsic or acquired resistance to azoles. Candida glabrata resistance to echinocandins is reported and is generally associated with previous use of echinocandins; FKS gene mutations have been associated with a worse outcome. We report the case of a 65-year-old woman who developed candidemia and endocarditis by C. glabrata with a newly acquired FKS mutation 24 months after successful treatment of infective endocarditis by C. glabrata with a double dosage of anidulafungin (200 mg daily) followed by oral voriconazole. Driven by high echinocandin MICs the strain taken by intraoperative cultures was further analyzed in a referral microbiology laboratory, confirming the new onset of point mutation S633P of the FKS2 gene.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Candidiasis
/
Proteínas Fúngicas
/
Mutación Puntual
/
Candida glabrata
/
Endocarditis
/
Anidulafungina
/
Antifúngicos
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Infez Med
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia