Reversal of Schizophrenia-like Symptoms and Cholinergic Alterations by Melatonin.
Arch Med Res
; 50(5): 295-303, 2019 07.
Article
en En
| MEDLINE
| ID: mdl-31600601
ABSTRACT
BACKGROUND:
Melatonin is a neurohormone that is linked to the pathogenesis of schizophrenia. The aim of this study was to assess the potential of melatonin in attenuating MK-801 induced schizophrenia-like behavioral and brain neurotoxicity markers.METHODS:
Swiss albino mice were assigned into three groups (n = 6). Animals were administered MK-801 (1 mg/kg/mL, i.p.). MK-801 treated animals were supplemented with melatonin (10 mg/kg/1 mL i.p.) 10 min prior to MK-801 injection. The relative degrees of modulation of induced behaviors by melatonin were assessed in the open field, elevated plus maze, grip strength and rota rod. The changes in neurotoxicity enzymes and neuronal activity (c-fos) were demonstrated in this study.RESULTS:
MK-801 injection effected normal open-field behaviors, c-fos expression, motor coordination and muscular strength. Melatonin was able to reduce the histological changes in the prefrontal cortex of mice brain.CONCLUSION:
Our data demonstrated that the treatment with melatonin attenuates the schizophrenic like symptoms in the mice having a protective effect on prefrontal cortex region of brain by mitigating the alteration of neurotoxicity markers. The protective effect of the treatment was shown to reduced elevation of AChE, c-fos expression and histopathological alterations.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Colinérgicos
/
Melatonina
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Arch Med Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
India