Pistacia weinmannifolia root exerts a protective role in ovalbumininduced lung inflammation in a mouse allergic asthma model.
Int J Mol Med
; 44(6): 2171-2180, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-31638171
ABSTRACT
Pistacia weinmannifolia (Anacardiaceae) has been used in herbal medicine for the treatment of influenza, dysentery and enteritis in China. It was recently observed that P. weinmannifolia root extract (PWRE) exerts antiinflammatory effects both in in vitro and in vivo models. Based on the results from previous studies, the present study investigated the protective effect of PWRE on airway inflammation and mucus hypersecretion. Treatment with PWRE significantly decreased the number of eosinophils and the levels of Th2 cytokines, such as interleukin (IL)4, IL5 and IL13, in the bronchoalveolar lavage fluid (BALF) of OVAexposed mice. PWRE decreased the high serum levels of total and OVAspecific immunoglobulin E. PWRE also effectively inhibited the influx of inflammatory cells into the lung, as well as airway mucus hypersecretion. In addition, the increased level of monocyte chemoattractant protein1 was significantly decreased with the PWRE treatment in the BALF of OVAexposed mice and in lipopolysaccharidestimulated RAW264.7 macrophages. These protective effects of PWRE on OVAinduced pulmonary inflammation were accompanied by the downregulation of mitogen associated protein kinases and nuclear factorκB activation. Thus, the results from the present study indicate that PWRE could be valuable adjuvant for the treatment of asthma.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neumonía
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Asma
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Extractos Vegetales
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Pistacia
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Mol Med
Año:
2019
Tipo del documento:
Article