KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction <i>via</i> NF-&#954;B-FGF21 or SREBP1c-FGF21 pathway.

Zhou, Lulu; Li, Qinjin; Chen, Ao; Liu, Na; Chen, Ning; Chen, Xiaojun; Zhu, Lin; Xia, Benzeng; Gong, Yuqing; Chen, Xiaodong

KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-κB-FGF21 or SREBP1c-FGF21 pathway.

Zhou, Lulu; Li, Qinjin; Chen, Ao; Liu, Na; Chen, Ning; Chen, Xiaojun; Zhu, Lin; Xia, Benzeng; Gong, Yuqing; Chen, Xiaodong.

Afiliación

Zhou L; Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Li Q; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Chen A; Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Liu N; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Chen N; Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Chen X; Institute of Biology and Medicine, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, China.
Zhu L; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Xia B; Key Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction, Ministry of Education, College of Animal Science and Technology and College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Gong Y; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.
Chen X; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China.

FASEB J ; 33(12): 14254-14269, 2019 12.

Article en En | MEDLINE | ID: mdl-31648561

Asunto(s)

Dieta Alta en Grasa/efectos adversos; Hígado Graso/inducido químicamente; Factores de Transcripción de Tipo Kruppel/metabolismo; FN-kappa B/metabolismo; Proteínas Represoras/metabolismo; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Proteína 1 Relacionada con Twist/metabolismo; Animales; ADN/genética; Grasas de la Dieta/efectos adversos; Ácidos Grasos no Esterificados/efectos adversos; Factores de Crecimiento de Fibroblastos/genética; Factores de Crecimiento de Fibroblastos/metabolismo; Regulación de la Expresión Génica/efectos de los fármacos; Técnicas de Silenciamiento del Gen; Células Hep G2; Humanos; Inflamación/metabolismo; Resistencia a la Insulina; Factores de Transcripción de Tipo Kruppel/genética; Masculino; Ratones; Ratones Endogámicos C57BL; Mitocondrias/efectos de los fármacos; FN-kappa B/genética; Células 3T3 NIH; Regiones Promotoras Genéticas; Unión Proteica; Células RAW 264.7; Proteínas Represoras/genética; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética; Proteína 1 Relacionada con Twist/genética

Palabras clave

NAFLD; endoplasmic reticulum stress; mitochondria; promoter

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Texto completo: 1 Asunto principal: Proteínas Represoras / FN-kappa B / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Proteína 1 Relacionada con Twist / Factores de Transcripción de Tipo Kruppel / Hígado Graso / Dieta Alta en Grasa Tipo de estudio: Prognostic_studies Idioma: En Revista: FASEB J Año: 2019 Tipo del documento: Article País de afiliación: China

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