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The relationship between prognostic nutritional index and treatment response in patients with metastatic renal cell cancer.
Yasar, Hatime Arzu; Bir Yucel, Kadriye; Arslan, Cagatay; Ucar, Gokhan; Karakaya, Serdar; Bilgin, Burak; Taban, Hakan; Kucukarda, Ahmet; Erturk, Ismail; Hizal, Mutlu; Yildiz, Birol; Yildirim, Nuriye; Demirci, Umut; Sendur, Mehmet Ali; Utkan, Gungor; Kilickap, Saadettin; Cicin, Irfan; Karadurmus, Nuri; Ürün, Yüksel.
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  • Yasar HA; Faculty of Medicine, Medical Oncology Department, Ankara University Ankara, Turkey.
  • Bir Yucel K; Cancer Research Institute, Ankara University, Ankara, Turkey.
  • Arslan C; Faculty of Medicine, Internal Medicine Department, Ankara University, Ankara, Turkey.
  • Ucar G; Faculty of Medicine, Department of Internal Medicine and Medical Oncology, Bahcesehir University, Istanbul, Turkey.
  • Karakaya S; Ankara Numune Education and Research Hospital, Medical Oncology Department, University of Health Sciences, Ankara, Turkey.
  • Bilgin B; Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Medical Oncology Department, University of Health Sciences, Ankara, Turkey.
  • Taban H; Faculty of Medicine, Medical Oncology Department, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Kucukarda A; Faculty of Medicine, Medical Oncology Department, Hacettepe University, Ankara, Turkey.
  • Erturk I; Faculty of Medicine, Department of Medical Oncology, Trakya University, Edirne, Turkey.
  • Hizal M; Gülhane Education and Research Hospital, Medical Oncology Department, University of Health Sciences, Ankara, Turkey.
  • Yildiz B; Faculty of Medicine, Medical Oncology Department, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Yildirim N; Gülhane Education and Research Hospital, Medical Oncology Department, University of Health Sciences, Ankara, Turkey.
  • Demirci U; Faculty of Medicine, Medical Oncology Department, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Sendur MA; Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Medical Oncology Department, University of Health Sciences, Ankara, Turkey.
  • Utkan G; Faculty of Medicine, Medical Oncology Department, Ankara Yildirim Beyazit University, Ankara, Turkey.
  • Kilickap S; Faculty of Medicine, Medical Oncology Department, Ankara University Ankara, Turkey.
  • Cicin I; Cancer Research Institute, Ankara University, Ankara, Turkey.
  • Karadurmus N; Faculty of Medicine, Medical Oncology Department, Hacettepe University, Ankara, Turkey.
  • Ürün Y; Faculty of Medicine, Department of Medical Oncology, Trakya University, Edirne, Turkey.
J Oncol Pharm Pract ; 26(5): 1110-1116, 2020 Jul.
Article en En | MEDLINE | ID: mdl-31653193
INTRODUCTION AND AIM: To investigate the effect of the prognostic nutritional index on treatment response and survival in patients with metastatic renal cell cancer. METHODS: We retrospectively analyzed the treatment modalities; the demographic, clinical and pathological features of 396 patients with RCC and prognostic nutritional index. Based on the median value, patients were grouped as having low and high prognostic nutritional index values. Kaplan-Meier method was used for survival analysis, and Cox-regression analysis was used for multivariate analysis. RESULTS: The median overall survival was 39 months (95% CI 26.1-51.8), 28 months (95% CI 17.9-38) and 7 months (95% CI 4.7-9.2) in patients with favorable, intermediate and poor International Metastatic Renal Cell Carcinoma Database Consortium risk group, respectively. The difference between the groups was statistically significant (p < 0001). Overall survival was 11 months (95% CI 7.5-14.5) in the low-prognostic nutritional index (prognostic nutritional index ≤38.5) group, and 41 months (95% CI 30.5-51.4) in the high prognostic nutritional index (prognostic nutritional index >38.5) group (p < 0.001). In Cox regression analysis, Eastern Cooperative Oncology Group performance score (HR: 2.5), time to systemic treatment (HR: 1.7) and prognostic nutritional index (HR: 1.8) were associated with overall survival. CONCLUSION: In patients with renal cell cancer, prognostic nutritional index is closely related to survival and has prognostic significance.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Trofoterapia Asunto principal: Carcinoma de Células Renales / Evaluación Nutricional / Neoplasias Renales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Oncol Pharm Pract Año: 2020 Tipo del documento: Article País de afiliación: Turquía
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Trofoterapia Asunto principal: Carcinoma de Células Renales / Evaluación Nutricional / Neoplasias Renales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Oncol Pharm Pract Año: 2020 Tipo del documento: Article País de afiliación: Turquía