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Sesquiterpenoids from the herbs of Solanum lyratum and their cytotoxicity on human hepatoma cells.
Li, Shuang-Shuang; Cheng, Zhuo-Yang; Zhang, Yang-Yang; Guo, Rui; Wang, Xiao-Bo; Huang, Xiao-Xiao; Li, Ling-Zhi; Song, Shao-Jiang.
Afiliación
  • Li SS; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
  • Cheng ZY; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
  • Zhang YY; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
  • Guo R; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
  • Wang XB; Chinese People's Liberation Army Logistics support force No.967 Hospital, Dalian 116021, PR China.
  • Huang XX; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: xiaoxiao270@163.com.
  • Li LZ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: lilingzhijessie@163.com.
  • Song SJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: songsj99@163.com.
Fitoterapia ; 139: 104411, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31705951
ABSTRACT
Eleven sesquiterpenoids including four new eudesmane sesquiterpenoids, solanoids A-D (1-4), and seven known compounds (5-11) were isolated from the herbs of Solanum lyratum. By analyzing the UV, MS and NMR data, the gross structures of all isolates were established. The absolute configurations of these new compounds were determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. The in vitro cytotoxicity of all isolates against the hepatocellular carcinoma Hep3B and HepG2 cell lines was evaluated. Among them, compounds 7 and 11 exhibited moderate cytotoxicity against two cell lines.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Solanum / Sesquiterpenos de Eudesmano / Antineoplásicos Fitogénicos País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Solanum / Sesquiterpenos de Eudesmano / Antineoplásicos Fitogénicos País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2019 Tipo del documento: Article