Sex-specific epigenetic alterations of the hypothalamic Agrp-Pomc system do not explain 'diabesity' in the offspring of high-fat diet (HFD) overfed maternal rats.

Schellong, Karen; Melchior, Kerstin; Ziska, Thomas; Henrich, Wolfgang; Rancourt, Rebecca C; Plagemann, Andreas

Schellong, Karen; Melchior, Kerstin; Ziska, Thomas; Henrich, Wolfgang; Rancourt, Rebecca C; Plagemann, Andreas.

Afiliación

Schellong K; Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.
Melchior K; Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.
Ziska T; Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.
Henrich W; Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.
Rancourt RC; Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany. Electronic address: rebecca.rancourt@charite.de.
Plagemann A; Division of 'Experimental Obstetrics', Clinic of Obstetrics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.

J Nutr Biochem ; 75: 108257, 2020 01.

Article en En | MEDLINE | ID: mdl-31710935

Asunto(s)

Proteína Relacionada con Agouti/genética; Diabetes Mellitus/genética; Epigénesis Genética; Hipotálamo/metabolismo; Obesidad/genética; Proopiomelanocortina/genética; Animales; Glucemia/análisis; Composición Corporal; Metilación de ADN; Complicaciones de la Diabetes; Dieta Alta en Grasa; Femenino; Masculino; Fenómenos Fisiologicos Nutricionales Maternos; Neuropéptidos/química; Hipernutrición/genética; Fenotipo; Embarazo; Preñez; Efectos Tardíos de la Exposición Prenatal/genética; Regiones Promotoras Genéticas; Ratas; Ratas Wistar; Factores Sexuales

Palabras clave

Epigenetics; Hypothalamic arcuate nucleus; Maternal high-fat diet; Neuropeptide expression; Nutritional programming; Offspring 'diabesity'

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proopiomelanocortina / Epigénesis Genética / Diabetes Mellitus / Proteína Relacionada con Agouti / Hipotálamo / Obesidad Idioma: En Revista: J Nutr Biochem Año: 2020 Tipo del documento: Article País de afiliación: Alemania

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