Extraction, structural characterization, and immunoregulatory effect of a polysaccharide fraction from Radix Aconiti Lateralis Preparata (Fuzi).
Int J Biol Macromol
; 143: 314-324, 2020 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-31786293
ABSTRACT
A water-soluble polysaccharide fraction named FZPS-1 was obtained from Radix Aconiti Lateralis Preparata (Fuzi in Chinese). Physicochemical and instrumental analyses indicated that the purified FZPS-1 with an average molecular weight of 6.29 × 106 Da was composed of D-arabinose and d-glucose with a molar ratio of 7.592.5. It would contain the main chain fragments of â4)-α-D-Glc-(1 â 4)-α-D-Glc-(1â, with the side chain of terminal α-L-Ara-(1 â linked at C6 of D-Glc skeleton. FZPS-1 exhibited significant antioxidative activity and immunomodulatory activity, wherein it promotes macrophage phagocytosis and increases the secretion of macrophage-derived biological factors in RAW 264.7 cells, and a cyclophosphamide-induced immunosuppressed model in a dose-dependent manner. Oral administration of FZPS-1 ameliorated chronic diarrhea in rhubarb-induced spleen deficiency rats and was related to its immunomodulatory activity. Therefore, the obtained FZPS-1 could be potentially utilized as a natural immunomodulatory agent in functional food supplements or drugs.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Polisacáridos
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Aconitum
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Inmunomodulación
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Biol Macromol
Año:
2020
Tipo del documento:
Article