Omega-3 fatty acid supplementation in pregnancy-baseline omega-3 status and early preterm birth: exploratory analysis of a randomised controlled trial.
BJOG
; 127(8): 975-981, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32034969
ABSTRACT
OBJECTIVE:
To identify a polyunsaturated fatty acid (PUFA) biomarker able to detect which women with singleton pregnancies are most likely to benefit from omega-3 supplementation to reduce their risk of early preterm birth.DESIGN:
Exploratory analysis of a randomised controlled trial.SETTING:
Six Australian hospitals. POPULATION Women with a singleton pregnancy enrolled in the ORIP trial.METHODS:
Using maternal capillary whole blood collected ~14 weeks' gestation, the fatty acids in total blood lipids were quantified using gas chromatography. Interaction tests examined whether baseline PUFA status modified the effect of omega-3 supplementation on birth outcomes. MAIN OUTCOMEMEASURE:
Early preterm birth (<34 weeks' gestation).RESULTS:
A low total omega-3 PUFA status in early pregnancy was associated with a higher risk of early preterm birth. Among women with a total omega-3 status ≤4.1% of total fatty acids, omega-3 supplementation substantially reduced the risk of early preterm birth compared with control (0.73 versus 3.16%; relative risk = 0.23, 95% confidence interval [CI] 0.07-0.79). Conversely, women with higher total omega-3 status in early pregnancy were at lower risk of early preterm birth. Supplementing women with a baseline status above 4.9% increased early preterm birth (2.20 versus 0.97%; relative risk = 2.27, 95% CI 1.13-4.58).CONCLUSIONS:
Women with singleton pregnancies and low total omega-3 PUFA status early in pregnancy have an increased risk of early preterm birth and are most likely to benefit from omega-3 supplementation to reduce this risk. Women with higher total omega-3 status are at lower risk and additional omega-3 supplementation may increase their risk. TWEETABLE ABSTRACT Low total omega-3 fat status helps identify which women benefit from extra omega-3 to reduce early prematurity.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Omega-3
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Nacimiento Prematuro
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Risk_factors_studies
País/Región como asunto:
Oceania
Idioma:
En
Revista:
BJOG
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia