Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis.

Zhang, Qin-Yu; Yan, Bing-Chao; Hu, Kun; Li, Xiao-Nian; Sun, Han-Dong; Puno, Pema-Tenzin

Zhang, Qin-Yu; Yan, Bing-Chao; Hu, Kun; Li, Xiao-Nian; Sun, Han-Dong; Puno, Pema-Tenzin.

Afiliación

Zhang QY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Re
Yan BC; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Hu K; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
Sun HD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address: hdsun@mail.kib.ac.cn.
Puno PT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China. Electronic address: punopematenzin@mail.kib.ac.cn.

Fitoterapia ; 142: 104529, 2020 Apr.

Article en En | MEDLINE | ID: mdl-32114037

ABSTRACT

ABSTRACT

Six new ent-kaurane diterpenoids, isorugosiformins A-F (1-6), were isolated from the aerial parts of Isodon rugosiformis Hand.-Mazz. Hara. Their structures were elucidated by spectroscopic data interpretation, single crystal X-ray diffraction, and quantum chemical calculation of NMR parameters. The absolute configuration of 5 as 6R was the first case in the known 6,78,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoids.

Asunto(s)

Diterpenos de Tipo Kaurano/aislamiento & purificación; Isodon/química; Animales; Línea Celular Tumoral; Diterpenos de Tipo Kaurano/química; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Ratones; Células RAW 264.7

Palabras clave

Ent-kaurane diterpenoids; Isodon rugosiformis; Quantum chemical calculation

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Isodon / Diterpenos de Tipo Kaurano Idioma: En Revista: Fitoterapia Año: 2020 Tipo del documento: Article