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A possible alternative therapy for type 2 diabetes using Myristica fragrans Houtt in combination with glimepiride: in vivo evaluation and in silico support.
Nasreen, Waheeda; Sarker, Suchitra; Sufian, Md Abu; Md Opo, F A Dain; Shahriar, Mohammad; Akhter, Rumana; Halim, Mohammad A.
Afiliación
  • Nasreen W; Department of Pharmacy, School of Medicine, University of Asia Pacific, 74/A Green Road, Dhaka 1215, Bangladesh, Phone: +8801711737697.
  • Sarker S; Department of Pharmacy, School of Medicine, University of Asia Pacific, 74/A Green Road, Dhaka 1215, Bangladesh.
  • Sufian MA; Department of Pharmacy, School of Medicine, University of Asia Pacific, 74/A Green Road, Dhaka 1215, Bangladesh.
  • Md Opo FAD; Division of Computer Aided Drug Design, The Red-Green Computing Centre, BICCB, 38 Green Road West, Dhaka 1205, Bangladesh.
  • Shahriar M; School of Pharmacy, Temple University, Philadelphia, USA.
  • Akhter R; Department of Pharmacy, School of Medicine, University of Asia Pacific, 74/A Green Road, Dhaka 1215, Bangladesh.
  • Halim MA; Department of Biological Science, King Abdulaziz University, Jeddha, Saudi Arabia.
Z Naturforsch C J Biosci ; 75(3-4): 103-112, 2020 Mar 26.
Article en En | MEDLINE | ID: mdl-32187019
The current study aimed to evaluate the in vivo hypoglycemic potential of Myristica fragrans seed extract co-administered with glimepiride in Swiss albino mice. Computational tools were used to further verify the in vivo findings and to help compare this combination to the glimepiride-pioglitazone combination in terms of the binding affinity of the ligands to their respective target protein receptors and the relative stability of the drug-protein complexes. The effect of the combined therapy was observed both in alloxan- and glucose-induced hyperglycemic Swiss albino mice. The mean fasting blood glucose level of the test groups was measured and statistically evaluated using Student's t test. The combined therapy significantly reduced the blood glucose level in a time-dependent manner compared to glimepiride alone. The binding affinity of glimepiride was found to be -7.6 kcal/mol with sulfonylurea receptor 1 in molecular docking. Conversely, macelignan-peroxisome proliferator-activated receptor (PPAR) α and macelignan-PPAR γ complexes were stabilized with -9.2 and -8.3 kcal/mol, respectively. Molecular dynamic simulation revealed that macelignan-PPAR α and γ complexes were more stable than pioglitazone complexes. The combination shows promise in animal and computer models and requires further trials to provide evidence of its activity in humans.
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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Compuestos de Sulfonilurea / Lignanos / Myristica / Diabetes Mellitus Tipo 2 / Hipoglucemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Z Naturforsch C J Biosci Año: 2020 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Terapias_biologicas / Aromoterapia Asunto principal: Compuestos de Sulfonilurea / Lignanos / Myristica / Diabetes Mellitus Tipo 2 / Hipoglucemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Z Naturforsch C J Biosci Año: 2020 Tipo del documento: Article