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GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats.
Li, Chunzhu; Yan, Jia; Tang, Dewei; Zhu, Jidong; Huang, Chen; Sun, Yu; Hu, Rong; Wang, Hao; Fu, Chaoying; Chen, Yelin; Jiang, Hong.
Afiliación
  • Li C; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, 200011, China.
  • Yan J; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, 200011, China.
  • Tang D; Center for Molecular Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, China.
  • Zhu J; Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Pudong New District, Shanghai, 200127, China.
  • Huang C; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.
  • Sun Y; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Hu R; College of Medical Imaging and Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
  • Wang H; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, 200011, China.
  • Fu C; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, 200011, China.
  • Chen Y; Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Center for Specialty Strategy Research of Shanghai Jiao Tong University China Hospital Development Institute, Shanghai, 200011, China.
  • Jiang H; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China.
Sci Rep ; 10(1): 5265, 2020 03 24.
Article en En | MEDLINE | ID: mdl-32210319
ABSTRACT
Anesthetics are used to produce hypnosis and analgesic effects during surgery, but anesthesia for a long time after the operation is not conducive to the recovery of animals or patients. Therefore, finding appropriate treatments to counter the effects of anesthetics could enhance postoperative recovery. In the current study, we discovered the novel role of a GluN2A-selective positive allosteric modulator (PAM) in ketamine-induced anesthesia and investigated the effects of the PAM combined with nalmefene and flumazenil (PNF) in reversing the actions of an anesthetic combination (ketamine-fentanyl-dexmedetomidine, KFD). PAM treatment dose-dependently decreased the duration of the ketamine-induced loss of righting reflex (LORR). Compared with those in the KFD group, the duration of LORR and the analgesic effect of the KFD + PNF group were obviously decreased. Meanwhile, successive administration of PNF and KFD had no adverse effects on the cardiovascular and respiratory systems. Both the KFD group and the KFD + PNF group showed no changes in hepatic and renal function or cognitive function in rats. Moreover, the recovery of motor coordination of the KFD + PNF group was faster than that of the KFD group. In summary, our results suggest the potential application of the PNF combination as an antagonistic treatment strategy for anesthesia.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fentanilo / Flumazenil / Receptores de N-Metil-D-Aspartato / Dexmedetomidina / Antagonistas de Receptores de GABA-A / Analgesia / Anestesia / Ketamina / Naltrexona / Antagonistas de Narcóticos Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fentanilo / Flumazenil / Receptores de N-Metil-D-Aspartato / Dexmedetomidina / Antagonistas de Receptores de GABA-A / Analgesia / Anestesia / Ketamina / Naltrexona / Antagonistas de Narcóticos Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: China