Phenylpropanoid-Conjugated Triterpenoids from the Leaves of Actinidia arguta and Their Inhibitory Activity on α-Glucosidase.
J Nat Prod
; 83(5): 1416-1423, 2020 05 22.
Article
en En
| MEDLINE
| ID: mdl-32315181
ABSTRACT
Actinidia arguta, commonly called hardy kiwifruit or kiwiberry, has cold-resistant properties and can be cultivated in Asia, including Korea. Seven new triterpenoids (2-4 and 8-11) along with eight known triterpenoids were isolated from the leaves of A. arguta through various chromatographic techniques. The new triterpenoids were defined as actiniargupenes A-C (2-4), actinidic acid derivatives with phenylpropanoid constituent units, dehydroisoactinidic acid (8), and actiniargupenes D-F (9-11), asiatic acid derivatives with phenylpropanoid substituents, on the basis of 1D and 2D NMR and MS data. Among the triterpenoids, those with a phenylpropanoid constituent unit showed inhibitory activity on α-glucosidase, which suggested the importance of the phenylpropanoid moiety. Molecular docking analysis demonstrated the interaction between the 4'-OH group of the phenylpropanoid moiety and α-glucosidase.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Triterpenos
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Hojas de la Planta
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Actinidia
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Alfa-Glucosidasas
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Nat Prod
Año:
2020
Tipo del documento:
Article