Functional disruption in prefrontal-striatal network in obsessive-compulsive disorder.
Psychiatry Res Neuroimaging
; 300: 111081, 2020 06 30.
Article
en En
| MEDLINE
| ID: mdl-32344156
ABSTRACT
Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors. While a cortico-striatal-limbic network has been implicated in the pathophysiology of OCD, the neural correlates of this network in OCD are not well understood. In this study, we examined resting state functional connectivity among regions within the cortico-striatal-limbic OCD neural network, including the rostral anterior cingulate cortex, dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, orbitofrontal cortex, ventromedial prefrontal cortex, amygdala, thalamus and caudate, in 44 OCD and 43 healthy participants. We then examined relationships between OCD neural network connectivity and OCD symptom severity in OCD participants. OCD relative to healthy participants showed significantly greater connectivity between the left caudate and bilateral dorsolateral prefrontal cortex. We also found a positive correlation between left caudate-bilateral dorsolateral prefrontal cortex connectivity and depression scores in OCD participants, such that greater positive connectivity was associated with more severe symptoms. This study makes a significant contribution to our understanding of functional networks and their relationship with depression in OCD.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Índice de Severidad de la Enfermedad
/
Imagen por Resonancia Magnética
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Red Nerviosa
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Trastorno Obsesivo Compulsivo
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Psychiatry Res Neuroimaging
Año:
2020
Tipo del documento:
Article