Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.

Okamura, Takuro; Hamaguchi, Masahide; Bamba, Ryo; Nakajima, Hanako; Yoshimura, Yuta; Kimura, Tomonori; Nishida, Kensuke; Hashimoto, Yoshitaka; Fukuda, Takuya; Senmaru, Takafumi; Fukui, Michiaki

Okamura, Takuro; Hamaguchi, Masahide; Bamba, Ryo; Nakajima, Hanako; Yoshimura, Yuta; Kimura, Tomonori; Nishida, Kensuke; Hashimoto, Yoshitaka; Fukuda, Takuya; Senmaru, Takafumi; Fukui, Michiaki.

Afiliación

Okamura T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Hamaguchi M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Bamba R; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Nakajima H; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Yoshimura Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Kimura T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Nishida K; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Hashimoto Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Fukuda T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Senmaru T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Fukui M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Am J Physiol Gastrointest Liver Physiol ; 318(6): G989-G999, 2020 06 01.

Article en En | MEDLINE | ID: mdl-32363890

Asunto(s)

Estradiol/farmacología; Enfermedad del Hígado Graso no Alcohólico/prevención & control; Testosterona/farmacología; Aminoácidos; Animales; Carcinoma Hepatocelular; Línea Celular Tumoral; Cromo; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Cadena alfa 1 del Colágeno Tipo I; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Dieta Alta en Grasa/efectos adversos; Regulación hacia Abajo; Estradiol/administración & dosificación; Regulación de la Expresión Génica/efectos de los fármacos; Humanos; Insulina; Cirrosis Hepática; Neoplasias Hepáticas; Masculino; Ratones; Ratones Noqueados; Ácidos Nicotínicos; Enfermedad del Hígado Graso no Alcohólico/patología; Orquiectomía; Células RAW 264.7; ARN Mensajero/genética; ARN Mensajero/metabolismo; Receptores CCR2/genética; Receptores CCR2/metabolismo; Testosterona/administración & dosificación; Testosterona/deficiencia; Factor de Crecimiento Transformador beta1/genética; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

ILC3; M2 macrophage; NASH; innate immunity; sex hormones

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Testosterona / Estradiol / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Prognostic_studies Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Año: 2020 Tipo del documento: Article País de afiliación: Japón

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