Metabolomics analyses to characterize metabolic alterations in Korean native calves by oral vitamin A supplementation.
Sci Rep
; 10(1): 8092, 2020 05 15.
Article
en En
| MEDLINE
| ID: mdl-32415141
ABSTRACT
Previous studies have reported that vitamin A administration in the birth stage of calves could promote preadipocyte and muscle development. However, the metabolic change after vitamin A administration remains unknown. Thus, the objective of this study was to perform metabonomics analyses to investigate the effect of vitamin A in Korean native calves. Ten newborn calves (initial average body weight 30.4 kg [SD 2.20]) were randomly divided into two groups treated with or without vitamin A supplementation (0 IU vs. 25,000 IU vitamin A/day) for two months until weaning. Metabolic changes in the serum and longissimus dorsi muscle of calves were investigated using GC-TOF-MS and multivariate statistical analysis. As a result, ten metabolic parameters in the serum and seven metabolic parameters in the longissimus dorsi muscle were down-regulated in the vitamin A treatment group compared to those in the control group (VIP value > 1.0, p < 0.05). Both serum and longissimus dorsi muscle showed lower levels of cholesterol and myo-inositol in the vitamin A treatment group than in the control group (p < 0.05). These results indicate that vitamin A supplementation in the early growth period of calf could maintain the preadipocyte status, which can contribute to future adipogenesis in the intramuscular fat production of Korean native cattle.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitamina A
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Suplementos Dietéticos
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Metaboloma
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Metabolómica
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Alimentación Animal
Idioma:
En
Revista:
Sci Rep
Año:
2020
Tipo del documento:
Article