Identification of Adenosine Deaminase Inhibitors by Metal-binding Pharmacophore Screening.

Adamek, Rebecca N; Ludford, Paul; Duggan, Stephanie M; Tor, Yitzhak; Cohen, Seth M

Adamek, Rebecca N; Ludford, Paul; Duggan, Stephanie M; Tor, Yitzhak; Cohen, Seth M.

Afiliación

Adamek RN; Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Ludford P; Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Duggan SM; Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Tor Y; Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.
Cohen SM; Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093, USA.

ChemMedChem ; 15(22): 2151-2156, 2020 11 18.

Article en En | MEDLINE | ID: mdl-32729197

Asunto(s)

Inhibidores de la Adenosina Desaminasa/farmacología; Adenosina Desaminasa/metabolismo; Oxazoles/farmacología; Zinc/farmacología; Inhibidores de la Adenosina Desaminasa/síntesis química; Inhibidores de la Adenosina Desaminasa/química; Relación Dosis-Respuesta a Droga; Evaluación Preclínica de Medicamentos; Humanos; Estructura Molecular; Oxazoles/química; Zinc/química

Palabras clave

Fluorescent Probes; Fragment Based Drug Discovery; High Throughput Screening; Medicinal Chemistry; Metalloenzymes

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxazoles / Zinc / Adenosina Desaminasa / Inhibidores de la Adenosina Desaminasa Tipo de estudio: Diagnostic_studies / Screening_studies Idioma: En Revista: ChemMedChem Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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