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Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice.
Wang, Junbiao; Iannarelli, Romilde; Pucciarelli, Stefania; Laudadio, Emiliano; Galeazzi, Roberta; Giangrossi, Mara; Falconi, Maurizio; Cui, Lishan; Navia, Aleix Marti; Buccioni, Michela; Marucci, Gabriella; Tomassoni, Daniele; Serini, Laura; Sut, Stefania; Maggi, Filippo; Dall'Acqua, Stefano; Marchini, Cristina; Amici, Augusto.
Afiliación
  • Wang J; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Iannarelli R; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
  • Pucciarelli S; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Laudadio E; Dipartimento Scienze e Ingegneria della Materia, dell'Ambiente ed Urbanistica, Università Politecnica delle Marche, Ancona, 60128, Italy.
  • Galeazzi R; Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, 60128, Italy.
  • Giangrossi M; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Falconi M; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Cui L; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Navia AM; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
  • Buccioni M; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
  • Marucci G; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
  • Tomassoni D; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Serini L; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
  • Sut S; DAFNAE Dipartimento di Agronomia, Animali, Alimenti, Risorse naturali e Ambiente, University of Padova, 35020, Legnaro, Italy.
  • Maggi F; School of Pharmacy, University of Camerino, 62032, Camerino, Italy.
  • Dall'Acqua S; DSF Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35121, Padova, Italy. Electronic address: stefano.dallacqua@unipd.it.
  • Marchini C; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy. Electronic address: cristina.marchini@unicam.it.
  • Amici A; School of Biosciences and Veterinary Medicine, University of Camerino, 62032, Camerino, Italy.
Pharmacol Res ; 161: 105123, 2020 11.
Article en En | MEDLINE | ID: mdl-32822867
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Neoplasias de la Mama / Antraquinonas / Receptor ErbB-2 / Lithospermum / Antagonistas del Ácido Fólico / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmacol Res Año: 2020 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Neoplasias de la Mama / Antraquinonas / Receptor ErbB-2 / Lithospermum / Antagonistas del Ácido Fólico / Antineoplásicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Pharmacol Res Año: 2020 Tipo del documento: Article País de afiliación: Italia