Evaluating triple ICS/LABA/LAMA therapies for COPD patients: a network meta-analysis of ETHOS, KRONOS, IMPACT, and TRILOGY studies.
Expert Rev Respir Med
; 15(1): 143-152, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-32856967
ABSTRACT
OBJECTIVES:
In some studies comparing triple with dual combination therapies in COPD there might be a possible effect of inhaler bias resulting from different inhaler devices being used in comparator arms. The aim of this study was a quantitative synthesis by considering the studies that directly compared triple ICS/LABA/LAMA vs. either dual LABA/LAMA or ICS/LABA therapies administered at fixed-dose combination (FDC) via the same inhaler device.METHODS:
A network meta-analysis was performed to assess the efficacy/safety impact of triple ICS/LABA/LAMA FDC compared with dual LABA/LAMA and ICS/LBA FDCs administered via the same inhaler device in COPD patients. The treatment ranking was reported via the surface under the cumulative ranking curve analysis (SUCRA).RESULTS:
Data obtained from 21,909 COPD patients were extracted from the ETHOS, KRONOS, IMPACT, and TRILOGY studies, the only that fulfilled the strict inclusion criteria of this research. The weighted efficacy/safety profile resulting from SUCRA provided the following ranking in patients with low eosinophil count ICS/LABA/LAMA>LABA/LAMAâ«ICS/LABA; whereas in patients with high eosinophil count the ranking was as follows ICS/LABA/LAMA>LABA/LAMA>ICS/LABA FDC.CONCLUSION:
Triple ICS/LABA/LAMA FDC and dual LABA/LAMA or ICS/LABA FDCs are characterized by specific efficacy/safety profiles in agreement with the level of blood eosinophil count at baseline.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Peloideterapia
Asunto principal:
Enfermedad Pulmonar Obstructiva Crónica
/
Agonistas de Receptores Adrenérgicos beta 2
Tipo de estudio:
Diagnostic_studies
/
Systematic_reviews
Idioma:
En
Revista:
Expert Rev Respir Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia