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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
Zima, Václav; Radilová, Katerina; Kozísek, Milan; Albiñana, Carlos Berenguer; Karlukova, Elena; Brynda, Jirí; Fanfrlík, Jindrich; Flieger, Miroslav; Hodek, Jan; Weber, Jan; Majer, Pavel; Konvalinka, Jan; Machara, Ales.
Afiliación
  • Zima V; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00, Prague 2, Czech Republic; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Radilová K; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic; First Faculty of Medicine, Charles University, Katerinská 1660, 121 08, Prague 2, Czech Republic.
  • Kozísek M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic. Electronic address: milan.kozisek@uochb.cas.cz.
  • Albiñana CB; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00, Prague 2, Czech Republic; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Karlukova E; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Brynda J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídenská 1083, 140 00, Prague 4, Czech Republic.
  • Fanfrlík J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Flieger M; Institute of Microbiology of the Czech Academy of Sciences, Vídenská 1083, 140 00, Prague 4, Czech Republic.
  • Hodek J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Weber J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Majer P; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic.
  • Konvalinka J; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic; Department of Biochemistry, Faculty of Science, Charles University, Hlavova 8, 128 00, Prague 2, Czech Republic.
  • Machara A; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00, Prague 2, Czech Republic; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Gilead Sciences and IOCB Research Center, Flemingovo n. 2, 166 10, Prague 6, Czech Republic. Electro
Eur J Med Chem ; 208: 112754, 2020 Dec 15.
Article en En | MEDLINE | ID: mdl-32883638
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Virus de la Influenza A / Proteínas Virales / Flavonoides / Endonucleasas / Inhibidores Enzimáticos Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: República Checa
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antivirales / Virus de la Influenza A / Proteínas Virales / Flavonoides / Endonucleasas / Inhibidores Enzimáticos Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: República Checa