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Lychee seed polyphenol protects the blood-brain barrier through inhibiting Aß(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.
Xiong, Rui; Zhou, Xiao-Gang; Tang, Yong; Wu, Jian-Ming; Sun, Yue-Shan; Teng, Jin-Feng; Pan, Rong; Law, Betty Yuen-Kwan; Zhao, Ya; Qiu, Wen-Qiao; Wang, Xiu-Ling; Liu, Sha; Wang, Yi-Ling; Yu, Lu; Yu, Chong-Lin; Mei, Qi-Bing; Qin, Da-Lian; Wu, An-Guo.
Afiliación
  • Xiong R; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Zhou XG; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Tang Y; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Wu JM; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Sun YS; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Teng JF; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Pan R; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Law BY; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Zhao Y; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Qiu WQ; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Wang XL; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Liu S; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Wang YL; Department of Human Anatomy, School of Preclinical Medicine, Southwest Medical University, Luzhou, China.
  • Yu L; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
  • Yu CL; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Mei QB; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
  • Qin DL; School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Wu AG; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chin
Phytother Res ; 35(2): 954-973, 2021 Feb.
Article en En | MEDLINE | ID: mdl-32893437

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Hirudoterapia Asunto principal: Semillas / Autofagia / Barrera Hematoencefálica / Litchi / Proteínas Quinasas Activadas por AMP / Inflamasomas / Enfermedad de Alzheimer / Polifenoles / Proteína con Dominio Pirina 3 de la Familia NLR Idioma: En Revista: Phytother Res Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Hirudoterapia Asunto principal: Semillas / Autofagia / Barrera Hematoencefálica / Litchi / Proteínas Quinasas Activadas por AMP / Inflamasomas / Enfermedad de Alzheimer / Polifenoles / Proteína con Dominio Pirina 3 de la Familia NLR Idioma: En Revista: Phytother Res Año: 2021 Tipo del documento: Article País de afiliación: China