Gambogic acid inhibits proliferation and induces apoptosis of human acute T­cell leukemia cells by inducing autophagy and downregulating ß­catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T­ALL cells.

Wang, Tongtong; Du, Jing; Kong, Dexia; Yang, Guosheng; Zhou, Qihao; You, Fei; Lin, Yan; Wang, Ying

Gambogic acid inhibits proliferation and induces apoptosis of human acute Tcell leukemia cells by inducing autophagy and downregulating ßcatenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on TALL cells.

Wang, Tongtong; Du, Jing; Kong, Dexia; Yang, Guosheng; Zhou, Qihao; You, Fei; Lin, Yan; Wang, Ying.

Afiliación

Wang T; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Du J; Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Kong D; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Yang G; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Zhou Q; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
You F; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Lin Y; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.
Wang Y; Department of General Practice, Wangjiangshan Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China.

Oncol Rep ; 44(4): 1747-1757, 2020 10.

Article en En | MEDLINE | ID: mdl-32945501

Asunto(s)

Glucógeno Sintasa Quinasa 3 beta/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamiento farmacológico; Xantonas/farmacología; beta Catenina/genética; Apoptosis/efectos de los fármacos; Autofagia/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Garcinia cambogia/química; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Medicina Tradicional China/métodos; Fosforilación/efectos de los fármacos; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/patología; Vía de Señalización Wnt/efectos de los fármacos

Palabras clave

T-cell acute lymphoblastic leukemia; gambogic acid; Wnt/ß-catenin; apoptosis; proliferation; autophagy

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Medicinas Tradicionales: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Xantonas / Beta Catenina / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Glucógeno Sintasa Quinasa 3 beta Tipo de estudio: Diagnostic_studies Idioma: En Revista: Oncol Rep Año: 2020 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google