Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1<i>&#945;</i> Signaling Pathways Mediated by the NAMPT-NAD Pathway.

Xie, Weijie; Zhu, Ting; Zhou, Ping; Xu, Huibo; Meng, Xiangbao; Ding, Tao; Nan, Fengwei; Sun, Guibo; Sun, Xiaobo

Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway.

Xie, Weijie; Zhu, Ting; Zhou, Ping; Xu, Huibo; Meng, Xiangbao; Ding, Tao; Nan, Fengwei; Sun, Guibo; Sun, Xiaobo.

Afiliación

Xie W; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Zhu T; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing 100193, China.
Zhou P; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Xu H; Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing 100193, China.
Meng X; Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Beijing 100193, China.
Ding T; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Nan F; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing 100193, China.
Sun G; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
Sun X; Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing 100193, China.

Oxid Med Cell Longev ; 2020: 7308386, 2020.

Article en En | MEDLINE | ID: mdl-33149812

Asunto(s)

Proteína Forkhead Box O3/metabolismo; NAD/metabolismo; Neuronas/patología; Nicotinamida Fosforribosiltransferasa/metabolismo; Panax notoginseng/química; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo; Sirtuinas/metabolismo; Triterpenos/farmacología; Acrilamidas/farmacología; Apoptosis/efectos de los fármacos; Hipoxia de la Célula/efectos de los fármacos; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Metabolismo Energético/efectos de los fármacos; Glucosa; Humanos; Isquemia/patología; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Modelos Biológicos; Necrosis; Neuronas/efectos de los fármacos; Neuronas/metabolismo; Oxígeno; Piperidinas/farmacología; Hojas de la Planta/química; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Superóxido Dismutasa/metabolismo; Regulación hacia Arriba/efectos de los fármacos

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Texto completo: 1 Asunto principal: Triterpenos / Sirtuinas / Panax notoginseng / Nicotinamida Fosforribosiltransferasa / Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma / Proteína Forkhead Box O3 / NAD / Neuronas Tipo de estudio: Prognostic_studies Idioma: En Revista: Oxid Med Cell Longev Año: 2020 Tipo del documento: Article País de afiliación: China

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