Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice.

Li, Meng; Zhou, Wenjun; Dang, Yanqi; Li, Chunlin; Ji, Guang; Zhang, Li

Li, Meng; Zhou, Wenjun; Dang, Yanqi; Li, Chunlin; Ji, Guang; Zhang, Li.

Afiliación

Li M; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Zhou W; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Dang Y; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Li C; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Ji G; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: jiliver@vip.sina.com.
Zhang L; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. Electronic address: zhangli.hl@163.com.

Biomed Pharmacother ; 132: 110953, 2020 Dec.

Article en En | MEDLINE | ID: mdl-33254441

Asunto(s)

Berberina/uso terapéutico; Microbioma Gastrointestinal/fisiología; Péptidos Similares al Glucagón/metabolismo; Hiperglucemia/tratamiento farmacológico; Hiperglucemia/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Animales; Berberina/farmacología; Colon/efectos de los fármacos; Colon/metabolismo; Microbioma Gastrointestinal/efectos de los fármacos; Péptidos Similares al Glucagón/agonistas; Masculino; Ratones; Ratones Endogámicos C57BL; Ratones Transgénicos; Receptores Acoplados a Proteínas G/agonistas

Palabras clave

Berberine compounds; Deoxycholic acid; Glucagon-like peptide; Gut microbiota; Hyperglycemia; Takeda G protein-coupled receptor 5

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Texto completo: 1 Bases de datos: MEDLINE Métodos Terapéuticos y Terapias MTCI: Plantas_medicinales Asunto principal: Berberina / Receptores Acoplados a Proteínas G / Péptidos Similares al Glucagón / Microbioma Gastrointestinal / Hiperglucemia Idioma: En Revista: Biomed Pharmacother Año: 2020 Tipo del documento: Article País de afiliación: China

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