Effect of light emitting diode photobiomodulation on murine macrophage function after Bothrops envenomation.
Chem Biol Interact
; 333: 109347, 2021 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-33259806
ABSTRACT
Several reports have suggested that photobiomodulation, owing to its analgesic, anti-inflammatory, and healing effects, may be an effective therapeutic option for local effects of snakebites when the availability and accessibility of conventional serum therapy are inefficient and far from medical care centers. Although there have been studies that demonstrate the application of photobiomodulation in the treatment of local adverse events due to snakebites from snakes of the genus Bothrops, its role in the activation of leukocytes, particularly macrophages, has not been evaluated. Here, we assessed the effect of light-emitting diode (LED) treatment on macrophage activation induced by B. jararacussu venom (BjV). LED treatment caused an increase in the viability of macrophages incubated with BjV. This treatment reduced reactive oxygen species (ROS) and nitric oxide (NO) production by macrophages after incubation with BjV. However, LED treatment did not interfere with IL-1ß and IL-10 production by macrophages after incubation with BjV. In conclusion, this study showed that LED treatment has the potential to be used in combination with conventional serum therapy to prevent or minimize the progression of local to severe symptoms after Bothrops envenomation.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_energeticas
Asunto principal:
Semiconductores
/
Mordeduras de Serpientes
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Bothrops
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Venenos de Crotálidos
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Terapia por Luz de Baja Intensidad
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Macrófagos
Idioma:
En
Revista:
Chem Biol Interact
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil